In vivo characterization of abdominal aortic aneurysms using an elastin specific molecular MR probe
نویسندگان
چکیده
Background Rupture of abdominal aortic aneurysms (AAAs) is the third most common cause of death in cardiovascular diseases. Despite this high significance, there is still controversy regarding the management of AAAs, as diameter is currently the only accepted parameter to assess risk of rupture. Elastin is the key protein for maintaining stability of the aortic wall. The aim of this study was to evaluate a novel small-molecular-weight elastin-specific MR probe for the in-vivo assessment of aortic wall integrity in AAAs.
منابع مشابه
Molecular assessment of aortic aneurysm wall integrity using an elastin-specific MR imaging probe
Background The incidence of abdominal aortic aneurysms (AAAs) has increased in western societies and complications often lead to life threatening events. There is still controversy regarding the management of medium sized AAAs. Therefore, novel biomarkers, besides aneurysmal diameter, are needed to assess aortic wall integrity and risk of rupture. Elastin is the key protein for maintaining stab...
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Background—The incidence of abdominal aortic aneurysms (AAAs) has increased during the last decades. However, there is still controversy regarding the management of medium-sized AAAs. Therefore novel biomarkers, besides aneurysmal diameter, are needed to assess aortic wall integrity and risk of rupture. Elastin is the key protein for maintaining aortic wall tensile strength and stability. The p...
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BACKGROUND The incidence of abdominal aortic aneurysms (AAAs) has increased during the last decades. However, there is still controversy about the management of medium-sized AAAs. Therefore, novel biomarkers, besides aneurysmal diameter, are needed to assess aortic wall integrity and risk of rupture. Elastin is the key protein for maintaining aortic wall tensile strength and stability. The prog...
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